Treatment With a Novel Hemigramicidin-TEMPO Conjugate Prolongs Survival in a Rat Model of Lethal Hemorrhagic Shock

摘要

A novel scavenger of reactive oxygen species that uses a fragment of the antibiotic, gramicidin, was synthesized to target the electron scavenger and superoxide dismutase mimic, 4-amino-2,2,6,6-tetramethylpiperidine-N-oxyl, to mitochondria. Delayed treatment with this compound significantly prolonged the survival of rats subjected to lethal hemorrhagic shock, even in the absence of resuscitation with asanguinous fluid or blood.